From the recent study, Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer, we see that if only the researchers were aware of the Tennant Polarity Theory for Cancer, that they may have been able to continue the research process in a parallel direction to their excellent work: not becoming stymied, but rather encouraged.
Neutrophils are a type of white blood cell essential to our immune systems needed for fighting pathogens. Causing a reduction of these cells in order to halt the spread of lung cancer is not a viable clinical solution, but this does teach us much more about lung cancer: the cancer with the worst response to immunotherapy.
This study shows that the immune cell termed "Gr1+ neutrophils" ironically contributed to the disease progression. These neutrophils were found to support tumor growth, thus preventing or inhibiting the success of anti-PD1 immunotherapy. They also changed how the tumors' blood vessels functioned.
When a tumor's blood vessels are altered, the presence of neutrophils reduces the amount of oxygen present. This leads to the production of a protein called Snail which helps tumors resist drugs, grow tumor cells and expand. More Snail encourages production of another protein termed Cxcl2, and this protein allows for neutrophil penetration. This self-promoting cycle is what speeds up the growth of the tumor.
We know from the Tennant Polarity Theory of Cancer that when oxygen is removed from a cell the polarity of that cell will shift due to the loss of electrons from a minus millivolt (mV) charge to a positive charge.
In the instance of this study, the researchers would be wise to look deeper into the molecular level of this interaction to find how they could prevent the polarity reversal in the first place so that oxygen could be maintained in the cells and thus prevent the proper environment for Snail to thrive.
We also need to investigate what is causing the neutrophils to alter the function of the tumor's blood vessels on a molecular level? The flow or lack of flow of electrons would seem to be an obvious consideration. With this change of focus, the neutrophils would not necessarily have to be considered the threat to the immunotherapy but rather the possibility of a reversed polarity itself or a remote source causing a drain on the electron flow to or within the blood vessels.